Wired (Game|Life) scored an interview with Rob Pardo who confirmed Diablo III will feature the anti-hack software from World of Warcraft known as Warden, except it will be adapted specifically for Diablo III. Pardo mentioned other measures will be taken to prevent hacking by means of third-party software.
Another question pitched at the Vice-president of Game Design was if Diablo III would include DRM to prevent piracy. Wired specifically compared Spore